A study was conducted to evaluate the histological alterations in the progeny of dams treated with methimazole, monocrotophos and lead acetate. Female pregnant albino rats of Wistar Kyoto strain were divided into 5 groups and treated as follows from the day 3 of pregnancy till weaning of pups on post-natal day (PND) 21: Group 1 served as sham control, 2 received methimazole @ 0.02% in drinking water, 3 received monocrotophos (MCP; 0.3 mg/kg orally), 4 received lead acetate @ 0.2% in drinking water and 5 received MCP + lead acetate. Thyroid hormone profile was recorded on 14th day of gestation in dams. Eight pups from each group were euthanized on PND 90 for studying testicular lactate dehydrogenase (LDH) and brain, thyroid, liver, heart, kidney and testis tissues were collected for histopathology. Testicular LDH was significantly (P < 0.05) increased in all the test groups as compared to group 1. Groups 2 (methimazole) and 5 (MCP + lead acetate) showed marked congestion and degenerative changes in liver, heart, kidney, brain and testis, while thyroid gland showed moderate disruption of follicular epithelium. Groups 3 and 4 revealed mild abnormalities. From this study, it is concluded that both MCP and lead acetate have a possible influence on thyroid gland and other tissues of progeny rats that were born to the dams treated with MCP and lead acetate and the changes were comparable to that of methimazole group.
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